Single-cell gene expression analyses reveal distinct self-renewing and proliferating subsets in the leukemia stem cell compartment in acute myeloid leukemia

Standard chemotherapy for acute myeloid leukemia (AML) targets proliferative cells and efficiently induces complete remission; however, many patients relapse and die of their disease. Relapse is caused by leukemia stem cells (LSCs), the cells with self-renewal capacity. Self-renewal and proliferatio...

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Bibliografiset tiedot
Julkaisussa:Cancer Res
Päätekijät: Sachs, Karen, Sarver, Aaron L., Noble-Orcutt, Klara E., LaRue, Rebecca S., Antony, Marie Lue, Chang, Daniel, Lee, Yoonkyu, Navis, Connor M., Hillesheim, Alexandria L., Nykaza, Ian R., Ha, Ngoc A., Hansen, Conner J., Karadag, Fatma K., Bergerson, Rachel J., Verneris, Michael R., Meredith, Matthew M., Schomaker, Matthew L., Linden, Michael A., Myers, Chad L., Largaespada, David A., Sachs, Zohar
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002190/
https://ncbi.nlm.nih.gov/pubmed/31784425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-2932
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