Single-cell gene expression analyses reveal distinct self-renewing and proliferating subsets in the leukemia stem cell compartment in acute myeloid leukemia

Standard chemotherapy for acute myeloid leukemia (AML) targets proliferative cells and efficiently induces complete remission; however, many patients relapse and die of their disease. Relapse is caused by leukemia stem cells (LSCs), the cells with self-renewal capacity. Self-renewal and proliferatio...

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Bibliografske podrobnosti
izdano v:Cancer Res
Main Authors: Sachs, Karen, Sarver, Aaron L., Noble-Orcutt, Klara E., LaRue, Rebecca S., Antony, Marie Lue, Chang, Daniel, Lee, Yoonkyu, Navis, Connor M., Hillesheim, Alexandria L., Nykaza, Ian R., Ha, Ngoc A., Hansen, Conner J., Karadag, Fatma K., Bergerson, Rachel J., Verneris, Michael R., Meredith, Matthew M., Schomaker, Matthew L., Linden, Michael A., Myers, Chad L., Largaespada, David A., Sachs, Zohar
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002190/
https://ncbi.nlm.nih.gov/pubmed/31784425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-2932
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