THE GENOMIC LANDSCAPE OF HYPODIPLOID ACUTE LYMPHOBLASTIC LEUKEMIA

The genetic basis of hypodiploid acute lymphoblastic leukemia (ALL), a subtype of ALL characterized by aneuploidy and poor outcome, is unknown. Genomic profiling of 124 hypodiploid ALL cases, including whole genome and exome sequencing of 40 cases, identified two subtypes that differ in severity of...

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Main Authors: Holmfeldt, Linda, Wei, Lei, Diaz-Flores, Ernesto, Walsh, Michael, Zhang, Jinghui, Ding, Li, Payne-Turner, Debbie, Churchman, Michelle, Andersson, Anna, Chen, Shann-Ching, McCastlain, Kelly, Becksfort, Jared, Ma, Jing, Wu, Gang, Patel, Samir N., Heatley, Susan L., Phillips, Letha A., Song, Guangchun, Easton, John, Parker, Matthew, Chen, Xiang, Rusch, Michael, Boggs, Kristy, Vadodaria, Bhavin, Hedlund, Erin, Drenberg, Christina, Baker, Sharyn, Pei, Deqing, Cheng, Cheng, Huether, Robert, Lu, Charles, Fulton, Robert S., Fulton, Lucinda L., Tabib, Yashodhan, Dooling, David J., Ochoa, Kerri, Minden, Mark, Lewis, Ian D., To, L. Bik, Marlton, Paula, Roberts, Andrew W., Raca, Gordana, Stock, Wendy, Neale, Geoffrey, Drexler, Hans G., Dickins, Ross A., Ellison, David W., Shurtleff, Sheila A., Pui, Ching-Hon, Ribeiro, Raul C., Devidas, Meenakshi, Carroll, Andrew J., Heerema, Nyla A., Wood, Brent, Borowitz, Michael J., Gastier-Foster, Julie M., Raimondi, Susana C., Mardis, Elaine R., Wilson, Richard K., Downing, James R., Hunger, Stephen P., Loh, Mignon L., Mullighan, Charles G.
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3919793/
https://ncbi.nlm.nih.gov/pubmed/23334668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2532
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