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p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal
The p53 tumor suppressor limits proliferation in response to cellular stress through several mechanisms. Here, we test whether the recently described ability of p53 to limit stem cell self-renewal suppresses tumorigenesis in acute myeloid leukemia (AML), an aggressive cancer in which p53 mutations a...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2895198/ https://ncbi.nlm.nih.gov/pubmed/20595231 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1940710 |
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