Direct and indirect targeting of MYC to treat acute myeloid leukemia

PURPOSE: Acute myeloid leukemia (AML) is the most common acute leukemia in adults and is often resistant to conventional therapies. The MYC oncogene is commonly overexpressed in AML but has remained an elusive target. We aimed to examine the consequences of targeting MYC both directly and indirectly...

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Detalhes bibliográficos
Publicado no:Cancer Chemother Pharmacol
Main Authors: Brondfield, Sam, Umesh, Sushma, Corella, Alexandra, Zuber, Johannes, Rappaport, Amy R., Gaillard, Coline, Lowe, Scott W., Goga, Andrei, Kogan, Scott C.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485702/
https://ncbi.nlm.nih.gov/pubmed/25956709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-015-2766-z
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