Phospholipase C γ and Phosphoinositide 3-Kinase Link Cytokines to ERK Activation in Hematopoietic Cells With Normal and Oncogenic Kras

Oncogenic K-Ras proteins, such as K-Ras(G12D), accumulate in the active, guanosine triphosphate (GTP)–bound conformation and stimulate signaling through effector kinases. The presence of the K-Ras(G12D) oncoprotein at a similar abundance to that of endogenous wild-type K-Ras results in only minimal...

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Detalhes bibliográficos
Main Authors: Diaz-Flores, Ernesto, Goldschmidt, Hana, Depeille, Philippe, Ng, Victor, Akutagawa, Jon, Krisman, Kimberly, Crone, Michael, Burgess, Michael R., Williams, Olusegun, Houseman, Benjamin, Shokat, Kevan, Sampath, Deepak, Bollag, Gideon, Roose, Jeroen P., Braun, Benjamin S., Shannon, Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117477/
https://ncbi.nlm.nih.gov/pubmed/24300897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2004125
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