Wake me when it’s over – Bacterial toxin–antitoxin proteins and induced dormancy

Por Coussens, Nathan P, Daines, Dayle A
Publicado no Exp Biol Med (Maywood) (2016)

Strategies for assessing proton linkage to bimolecular interactions by global analysis of isothermal titration calorimetry data

Por Coussens, Nathan P., Schuck, Peter, Zhao, Huaying
Publicado em 2012

AlphaScreen-Based Assays: Ultra-High-Throughput Screening for Small-Molecule Inhibitors of Challenging Enzymes and Protein-Protein Interactions

Por Yasgar, Adam, Jadhav, Ajit, Simeonov, Anton, Coussens, Nathan P.
Publicado no Methods Mol Biol (2016)

Crystal Structure of the Nod1 Caspase Activation and Recruitment Domain

Por Coussens, Nathan P., Mowers, Jonathan C., McDonald, Christine, Nuñez, Gabriel, Ramaswamy, S.
Publicado em 2006

The LAT Story: A Tale of Cooperativity, Coordination, and Choreography

Por Balagopalan, Lakshmi, Coussens, Nathan P., Sherman, Eilon, Samelson, Lawrence E., Sommers, Connie L.
Publicado em 2010

The Linker for Activation of T Cells (LAT) Signaling Hub: From Signaling Complexes to Microclusters

Por Balagopalan, Lakshmi, Kortum, Robert L., Coussens, Nathan P., Barr, Valarie A., Samelson, Lawrence E.
Publicado no J Biol Chem (2015)

Small-Molecule Screens: A Gateway to Cancer Therapeutic Agents with Case Studies of Food and Drug Administration–Approved Drugs

Por Coussens, Nathan P., Braisted, John C., Peryea, Tyler, Sittampalam, G. Sitta, Simeonov, Anton, Hall, Matthew D.
Publicado no Pharmacol Rev (2017)

Isolation of an endotoxin–MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations

Por Gioannini, Theresa L., Teghanemt, Athmane, Zhang, DeSheng, Coussens, Nathan P., Dockstader, Wendie, Ramaswamy, S., Weiss, Jerrold P.
Publicado em 2004

Fluorescence polarization assays in high-throughput screening and drug discovery: a review

Por Hall, Matthew D, Yasgar, Adam, Peryea, Tyler, Braisted, John C, Jadhav, Ajit, Simeonov, Anton, Coussens, Nathan P
Publicado no Methods Appl Fluoresc (2016)

Better living through chemistry: Addressing emerging antibiotic resistance

Por Coussens, Nathan P, Molinaro, Ashley L, Culbertson, Kayla J, Peryea, Tyler, Zahoránszky-Köhalmi, Gergely, Hall, Matthew D, Daines, Dayle A
Publicado no Exp Biol Med (Maywood) (2018)

Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3

Por Tang, Liu-Ya, Yamashita, Motozo, Coussens, Nathan P, Tang, Yi, Wang, Xiangchun, Li, Cuiling, Deng, Chu-Xia, Cheng, Steven Y, Zhang, Ying E
Publicado em 2011

Structure of a heterogeneous, glycosylated, lipid-bound, in vivo-grown protein crystal at atomic resolution from the viviparous cockroach Diploptera punctata

Por Banerjee, Sanchari, Coussens, Nathan P., Gallat, François-Xavier, Sathyanarayanan, Nitish, Srikanth, Jandhyam, Yagi, Koichiro J., Gray, James S. S., Tobe, Stephen S., Stay, Barbara, Chavas, Leonard M. G., Ramaswamy, Subramanian
Publicado no IUCrJ (2016)

Multipoint Binding of the SLP-76 SH2 Domain to ADAP Is Critical for Oligomerization of SLP-76 Signaling Complexes in Stimulated T Cells

Por Coussens, Nathan P., Hayashi, Ryo, Brown, Patrick H., Balagopalan, Lakshmi, Balbo, Andrea, Akpan, Itoro, Houtman, Jon C. D., Barr, Valarie A., Schuck, Peter, Appella, Ettore, Samelson, Lawrence E.
Publicado em 2013

Identification of Novel Plasmodium falciparum Hexokinase Inhibitors with Antiparasitic Activity

Por Davis, Mindy I., Patrick, Stephen L., Blanding, Walker M., Dwivedi, Varun, Suryadi, Jimmy, Golden, Jennifer E., Coussens, Nathan P., Lee, Olivia W., Shen, Min, Boxer, Matthew B., Hall, Matthew D., Sharlow, Elizabeth R., Drew, Mark E., Morris, James C.
Publicado no Antimicrob Agents Chemother (2016)

A widely-applicable high-throughput cellular thermal shift assay (CETSA) using split Nano Luciferase

Por Martinez, Natalia J., Asawa, Rosita R., Cyr, Matthew G., Zakharov, Alexey, Urban, Daniel J., Roth, Jacob S., Wallgren, Eric, Klumpp-Thomas, Carleen, Coussens, Nathan P., Rai, Ganesha, Yang, Shyh-Ming, Hall, Matthew D., Marugan, Juan J., Simeonov, Anton, Henderson, Mark J.
Publicado no Sci Rep (2018)

High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2

Por Coussens, Nathan P., Kales, Stephen C., Henderson, Mark J., Lee, Olivia W., Horiuchi, Kurumi Y., Wang, Yuren, Chen, Qing, Kuznetsova, Ekaterina, Wu, Jianghong, Chakka, Sirisha, Cheff, Dorian M., Cheng, Ken Chih-Chien, Shinn, Paul, Brimacombe, Kyle R., Shen, Min, Simeonov, Anton, Lal-Nag, Madhu, Ma, Haiching, Jadhav, Ajit, Hall, Matthew D.
Publicado no J Biol Chem (2018)

In vivo crystallography at X-ray free-electron lasers: the next generation of structural biology?

Por Gallat, François-Xavier, Matsugaki, Naohiro, Coussens, Nathan P., Yagi, Koichiro J., Boudes, Marion, Higashi, Tetsuya, Tsuji, Daisuke, Tatano, Yutaka, Suzuki, Mamoru, Mizohata, Eiichi, Tono, Kensuke, Joti, Yasumasa, Kameshima, Takashi, Park, Jaehyun, Song, Changyong, Hatsui, Takaki, Yabashi, Makina, Nango, Eriko, Itoh, Kohji, Coulibaly, Fasséli, Tobe, Stephen, Ramaswamy, S., Stay, Barbara, Iwata, So, Chavas, Leonard M. G.
Publicado em 2014