GTP-binding Protein-like Domain of AGAP1 Is Protein Binding Site That Allosterically Regulates ArfGAP Protein Catalytic Activity

Por Luo, Ruibai, Akpan, Itoro O., Hayashi, Ryo, Sramko, Marek, Barr, Valarie, Shiba, Yoko, Randazzo, Paul A.
Publicado em 2012

In vivo functional mapping of the conserved protein domains within murine Themis1

Por Zvezdova, Ekaterina, Lee, Jan, El-Khoury, Dalal, Barr, Valarie, Akpan, Itoro, Samelson, Lawrence, Love, Paul E.
Publicado no Immunol Cell Biol (2014)

Development of nanoscale structure in LAT-based signaling complexes

Por Barr, Valarie A., Sherman, Eilon, Yi, Jason, Akpan, Itoro, Rouquette-Jazdanian, Alexandre K., Samelson, Lawrence E.
Publicado no J Cell Sci (2016)

Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation

Por Balagopalan, Lakshmi, Ashwell, Benjamin A., Bernot, Kelsie M., Akpan, Itoro O., Quasba, Naeha, Barr, Valarie A., Samelson, Lawrence E.
Publicado em 2011

The Cish SH2 domain is essential for PLC-γ1 regulation in TCR stimulated CD8(+) T cells

Por Guittard, Geoffrey, Dios-Esponera, Ana, Palmer, Douglas C., Akpan, Itoro, Barr, Valarie A., Manna, Asit, Restifo, Nicholas P., Samelson, Lawrence E.
Publicado no Sci Rep (2018)

Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor

Por Sherman, Eilon, Barr, Valarie, Manley, Suliana, Patterson, George, Balagopalan, Lakshmi, Akpan, Itoro, Regan, Carole K., Merrill, Robert K., Sommers, Connie L., Lippincott-Schwartz, Jennifer, Samelson, Lawrence E.
Publicado em 2011

Multipoint Binding of the SLP-76 SH2 Domain to ADAP Is Critical for Oligomerization of SLP-76 Signaling Complexes in Stimulated T Cells

Por Coussens, Nathan P., Hayashi, Ryo, Brown, Patrick H., Balagopalan, Lakshmi, Balbo, Andrea, Akpan, Itoro, Houtman, Jon C. D., Barr, Valarie A., Schuck, Peter, Appella, Ettore, Samelson, Lawrence E.
Publicado em 2013

The Ability of Sos1 to Oligomerize the Adaptor Protein LAT Is Separable from its Guanine Nucleotide Exchange Activity In Vivo

Por Kortum, Robert L., Balagopalan, Lakshmi, Alexander, Clayton P., Garcia, Julie, Pinski, John M., Merrill, Robert K., Nguyen, Phan H., Li, Wenmei, Agarwal, Isha, Akpan, Itoro O., Sommers, Connie L., Samelson, Lawrence E.
Publicado no Sci Signal (2013)

Intensity and duration of TCR signaling is limited by p38 phosphorylation of ZAP-70(T293) and destabilization of the signalosome

Por Giardino Torchia, Maria Letizia, Dutta, Debjani, Mittelstadt, Paul R., Guha, June, Gaida, Matthias M., Fish, Kamonwan, Barr, Valarie A., Akpan, Itoro O., Samelson, Lawrence E., Tagad, Harichandra D., Debnath, Subrata, Miller Jenkins, Lisa M., Appella, Ettore, Ashwell, Jonathan D.
Publicado no Proc Natl Acad Sci U S A (2018)