Intensity and duration of TCR signaling is limited by p38 phosphorylation of ZAP-70(T293) and destabilization of the signalosome

ZAP-70 is a tyrosine kinase that is essential for initiation of T cell antigen receptor (TCR) signaling. We have found that T cell p38 MAP kinase (MAPK), which is directly phosphorylated and activated by ZAP-70 downstream of the TCR, in turn phosphorylates Thr-293 in the interdomain B region of ZAP-...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Giardino Torchia, Maria Letizia, Dutta, Debjani, Mittelstadt, Paul R., Guha, June, Gaida, Matthias M., Fish, Kamonwan, Barr, Valarie A., Akpan, Itoro O., Samelson, Lawrence E., Tagad, Harichandra D., Debnath, Subrata, Miller Jenkins, Lisa M., Appella, Ettore, Ashwell, Jonathan D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834678/
https://ncbi.nlm.nih.gov/pubmed/29440413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1713301115
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