Intensity and duration of TCR signaling is limited by p38 phosphorylation of ZAP-70(T293) and destabilization of the signalosome

ZAP-70 is a tyrosine kinase that is essential for initiation of T cell antigen receptor (TCR) signaling. We have found that T cell p38 MAP kinase (MAPK), which is directly phosphorylated and activated by ZAP-70 downstream of the TCR, in turn phosphorylates Thr-293 in the interdomain B region of ZAP-...

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Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Giardino Torchia, Maria Letizia, Dutta, Debjani, Mittelstadt, Paul R., Guha, June, Gaida, Matthias M., Fish, Kamonwan, Barr, Valarie A., Akpan, Itoro O., Samelson, Lawrence E., Tagad, Harichandra D., Debnath, Subrata, Miller Jenkins, Lisa M., Appella, Ettore, Ashwell, Jonathan D.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2018
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834678/
https://ncbi.nlm.nih.gov/pubmed/29440413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1713301115
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