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Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation

Linker for activation of T cells (LAT) plays a central role in T-cell activation by nucleating signaling complexes that are critical for the propagation of T-cell signals from the plasma membrane to the cellular interior. The role of phosphorylation and palmitoylation in LAT function has been well s...

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Detalhes bibliográficos
Main Authors: Balagopalan, Lakshmi, Ashwell, Benjamin A., Bernot, Kelsie M., Akpan, Itoro O., Quasba, Naeha, Barr, Valarie A., Samelson, Lawrence E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041139/
https://ncbi.nlm.nih.gov/pubmed/21282648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1007098108
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