Microclusters as T Cell Signaling Hubs: Structure, Kinetics, and Regulation

por Balagopalan, Lakshmi, Raychaudhuri, Kumarkrishna, Samelson, Lawrence E.
Publicado en Front Cell Dev Biol (2021)

Endocytic events in TCR signaling: focus on adapters in microclusters

por Balagopalan, Lakshmi, Barr, Valarie A., Samelson, Lawrence E.
Publicado 2009

Imaging techniques for assaying lymphocyte activation in action

por Balagopalan, Lakshmi, Sherman, Eilon, Barr, Valarie A., Samelson, Lawrence E.
Publicado 2011

Cytoskeletal forces during signaling activation in Jurkat T-cells

por Hui, King Lam, Balagopalan, Lakshmi, Samelson, Lawrence E., Upadhyaya, Arpita
Publicado en Mol Biol Cell (2015)

The CDM Superfamily Protein MBC Directs Myoblast Fusion through a Mechanism That Requires Phosphatidylinositol 3,4,5-Triphosphate Binding but Is Independent of Direct Interaction w...

por Balagopalan, Lakshmi, Chen, Mei-Hui, Geisbrecht, Erika R., Abmayr, Susan M.
Publicado 2006

The LAT Story: A Tale of Cooperativity, Coordination, and Choreography

por Balagopalan, Lakshmi, Coussens, Nathan P., Sherman, Eilon, Samelson, Lawrence E., Sommers, Connie L.
Publicado 2010

TCR microclusters form spatially segregated domains and sequentially assemble in calcium-dependent kinetic steps

por Yi, Jason, Balagopalan, Lakshmi, Nguyen, Tiffany, McIntire, Katherine M., Samelson, Lawrence E.
Publicado en Nat Commun (2019)

Cell surface LAT is recruited to microclusters and is active in signaling

por Balagopalan, Lakshmi, Barr, Valarie A., Kortum, Robert L., Park, Anna K., Samelson, Lawrence E.
Publicado 2013

The Linker for Activation of T Cells (LAT) Signaling Hub: From Signaling Complexes to Microclusters

por Balagopalan, Lakshmi, Kortum, Robert L., Coussens, Nathan P., Barr, Valarie A., Samelson, Lawrence E.
Publicado en J Biol Chem (2015)

Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T cells leads to PI3K pathway activation and defects in migration

por Guittard, Geoffrey, Kortum, Robert L, Balagopalan, Lakshmi, Çuburu, Nicolas, Nguyen, Phan, Sommers, Connie L, Samelson, Lawrence E
Publicado en Eur J Immunol (2015)

Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation

por Balagopalan, Lakshmi, Yi, Jason, Nguyen, Tiffany, McIntire, Katherine M., Harned, Adam S., Narayan, Kedar, Samelson, Lawrence E.
Publicado en Nat Commun (2018)

c-Cbl-Mediated Regulation of LAT-Nucleated Signaling Complexes

por Balagopalan, Lakshmi, Barr, Valarie A., Sommers, Connie L., Barda-Saad, Mira, Goyal, Amrita, Isakowitz, Matthew S., Samelson, Lawrence E.
Publicado 2007

Cooperative assembly of a four-molecule signaling complex formed upon T cell antigen receptor activation

por Manna, Asit, Zhao, Huaying, Wada, Junya, Balagopalan, Lakshmi, Tagad, Harichandra D., Appella, Ettore, Schuck, Peter, Samelson, Lawrence E.
Publicado en Proc Natl Acad Sci U S A (2018)

Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation

por Balagopalan, Lakshmi, Ashwell, Benjamin A., Bernot, Kelsie M., Akpan, Itoro O., Quasba, Naeha, Barr, Valarie A., Samelson, Lawrence E.
Publicado 2011

Bypassing ubiquitination enables LAT recycling to the cell surface and enhanced signaling in T cells

por Balagopalan, Lakshmi, Malik, Hiba, McIntire, Katherine M., Garvey, Joseph A., Nguyen, Tiffany, Rodriguez-Peña, Ana B., Samelson, Lawrence E.
Publicado en PLoS One (2020)

Enhanced Function of Redirected Human T Cells Expressing Linker for Activation of T Cells That Is Resistant to Ubiquitylation

por Kunii, Naoki, Zhao, Yangbing, Jiang, Shuguang, Liu, Xiaojun, Scholler, John, Balagopalan, Lakshmi, Samelson, Lawrence E., Milone, Michael C., June, Carl H.
Publicado 2013

Cish actively silences tcr signaling in CD8+ T cells to maintain tumor tolerance

por Palmer, Douglas, Guittard, Geoff, Franco, Zulmarie, Patel, Shashank, Klebanoff, Christopher A, Sukumar, Madhusudhanan, Eil, Robert L, Clever, David, Balagopalan, Lakshmi, Roychoudhuri, Rahul, Samelson, Larry, Restifo, Nicholas
Publicado en J Immunother Cancer (2015)

Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor

por Sherman, Eilon, Barr, Valarie, Manley, Suliana, Patterson, George, Balagopalan, Lakshmi, Akpan, Itoro, Regan, Carole K., Merrill, Robert K., Sommers, Connie L., Lippincott-Schwartz, Jennifer, Samelson, Lawrence E.
Publicado 2011

Multipoint Binding of the SLP-76 SH2 Domain to ADAP Is Critical for Oligomerization of SLP-76 Signaling Complexes in Stimulated T Cells

por Coussens, Nathan P., Hayashi, Ryo, Brown, Patrick H., Balagopalan, Lakshmi, Balbo, Andrea, Akpan, Itoro, Houtman, Jon C. D., Barr, Valarie A., Schuck, Peter, Appella, Ettore, Samelson, Lawrence E.
Publicado 2013

Dynamic Movement of the Calcium Sensor STIM1 and the Calcium Channel Orai1 in Activated T-Cells: Puncta and Distal Caps

por Barr, Valarie A., Bernot, Kelsie M., Srikanth, Sonal, Gwack, Yousang, Balagopalan, Lakshmi, Regan, Carole K., Helman, Daniel J., Sommers, Connie L., Oh-hora, Masatsugu, Rao, Anjana, Samelson, Lawrence E.
Publicado 2008