A trapped human PPM1A–phosphopeptide complex reveals structural features critical for regulation of PPM protein phosphatase activity

Metal-dependent protein phosphatases (PPM) are evolutionarily unrelated to other serine/threonine protein phosphatases and are characterized by their requirement for supplementation with millimolar concentrations of Mg(2+) or Mn(2+) ions for activity in vitro. The crystal structure of human PPM1A (a...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Debnath, Subrata, Kosek, Dalibor, Tagad, Harichandra D., Durell, Stewart R., Appella, Daniel H., Acevedo, Roderico, Grishaev, Alexander, Dyda, Fred, Appella, Ettore, Mazur, Sharlyn J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971455/
https://ncbi.nlm.nih.gov/pubmed/29602904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001213
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