Optimization of a Cyclic Peptide Inhibitor of Ser/Thr Phosphatase PPM1D (Wip1)()

PPM1D (PP2Cδ or Wip1) was identified as a wild type p53-induced Ser/Thr phosphatase that accumulates after DNA damage and classified into the PP2C family. It dephosphorylates and inactivates several proteins critical for cellular stress responses, including p38 MAPK, p53, and ATM. Furthermore, PPM1D...

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Bibliographic Details
Main Authors: Hayashi, Ryo, Tanoue, Kan, Durell, Stewart R., Chatterjee, Deb K., Miller Jenkins, Lisa M., Appella, Daniel H., Appella, Ettore
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3508689/
https://ncbi.nlm.nih.gov/pubmed/21528848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101949t
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