A Small Molecular Scaffold for Selective Inhibition of Wip1 Phosphatase()

Using a pyrrole-based scaffold, we developed a series of small molecules that mimic the three-dimensional arrangement of the polar and hydrophobic functional groups of the best cyclic-peptide inhibitor. Iterative optimization cycles of design, synthesis and kinetic testing has lead to an effective i...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Bang, Jeong, Yamaguchi, Hiroshi, Durell, Stewart R., Appella, Ettore, Appella, Daniel H.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824627/
https://ncbi.nlm.nih.gov/pubmed/18022979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.200700281
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker