Binding of a Third Metal Ion by the Human Phosphatases PP2Cα and Wip1 is Required for Phosphatase Activity

The PPM phosphatases require millimolar concentrations of Mg(2+) or Mn(2+) to activate phosphatase activity in vitro. The human phosphatases PP2Cα (PPM1A) and Wip1 (PPM1D) differ in their physiological function, substrate specificity, and apparent metal affinity. A crystallographic structure of PP2C...

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Main Authors: Tanoue, Kan, Miller Jenkins, Lisa M., Durell, Stewart R., Debnath, Subrata, Sakai, Hiroyasu, Tagad, Harichandra D., Ishida, Kazushige, Appella, Ettore, Mazur, Sharlyn J.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824971/
https://ncbi.nlm.nih.gov/pubmed/23906386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi4005649
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