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Binding of a Third Metal Ion by the Human Phosphatases PP2Cα and Wip1 is Required for Phosphatase Activity
The PPM phosphatases require millimolar concentrations of Mg(2+) or Mn(2+) to activate phosphatase activity in vitro. The human phosphatases PP2Cα (PPM1A) and Wip1 (PPM1D) differ in their physiological function, substrate specificity, and apparent metal affinity. A crystallographic structure of PP2C...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3824971/ https://ncbi.nlm.nih.gov/pubmed/23906386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi4005649 |
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