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Chemical features important for activity in a class of inhibitors targeting the Wip1 flap subdomain
The wild-type p53 induced phosphatase 1, Wip1 (PP2Cδ), is a PP2C family Ser/Thr phosphatase that negatively regulates the function of multiple proteins such as p53, ATM, Chk1, Chk2, Mdm2 and p38 MAPK involved in a DNA damage response. Wip1 dephosphorylates and inactivates its protein targets which a...
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| Publicado no: | ChemMedChem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8022280/ https://ncbi.nlm.nih.gov/pubmed/29476592 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700779 |
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