Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens

WT P53-Induced Phosphatase 1 (WIP1) is a member of the magnesium-dependent serine/threonine protein phosphatase (PPM) family and is induced by P53 in response to DNA damage. In several human cancers, the WIP1 protein is overexpressed, which is generally associated with a worse prognosis. Although WI...

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Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Clausse, Victor, Tao, Dingyin, Debnath, Subrata, Fang, Yuhong, Tagad, Harichandra D., Wang, Yuhong, Sun, Hongmao, LeClair, Christopher A., Mazur, Sharlyn J., Lane, Kelly, Shi, Zhen-Dan, Vasalatiy, Olga, Eells, Rebecca, Baker, Lynn K., Henderson, Mark J., Webb, Martin R., Shen, Min, Hall, Matthew D., Appella, Ettore, Appella, Daniel H., Coussens, Nathan P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2019
Gaiak:
Methods and Resources
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6873202/
https://ncbi.nlm.nih.gov/pubmed/31481464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010201
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