Загрузка...
Chemical features important for activity in a class of inhibitors targeting the Wip1 flap subdomain
The wild-type p53 induced phosphatase 1, Wip1 (PP2Cδ), is a PP2C family Ser/Thr phosphatase that negatively regulates the function of multiple proteins such as p53, ATM, Chk1, Chk2, Mdm2 and p38 MAPK involved in a DNA damage response. Wip1 dephosphorylates and inactivates its protein targets which a...
Сохранить в:
| Опубликовано в: : | ChemMedChem |
|---|---|
| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2018
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8022280/ https://ncbi.nlm.nih.gov/pubmed/29476592 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700779 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|