Chemical features important for activity in a class of inhibitors targeting the Wip1 flap subdomain

The wild-type p53 induced phosphatase 1, Wip1 (PP2Cδ), is a PP2C family Ser/Thr phosphatase that negatively regulates the function of multiple proteins such as p53, ATM, Chk1, Chk2, Mdm2 and p38 MAPK involved in a DNA damage response. Wip1 dephosphorylates and inactivates its protein targets which a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:ChemMedChem
Hauptverfasser: Tagad, Harichandra D., Debnath, Subrata, Clausse, Victor, Saha, Mrinmoy, Mazur, Sharlyn, Appella, Ettore, Appella, Daniel H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8022280/
https://ncbi.nlm.nih.gov/pubmed/29476592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700779
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge