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The Cish SH2 domain is essential for PLC-γ1 regulation in TCR stimulated CD8(+) T cells
Cish, participates within a multi-molecular E3 ubiquitin ligase complex, which ubiquitinates target proteins. It has an inhibitory effect on T cell activation mediated by PLC-γ1 regulation, and it functions as a potent checkpoint in CD8(+) T cell tumor immunotherapy. To study the structural and func...
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| Pubblicato in: | Sci Rep |
|---|---|
| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5871872/ https://ncbi.nlm.nih.gov/pubmed/29593227 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23549-2 |
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