Cish actively silences TCR signaling in CD8(+) T cells to maintain tumor tolerance

Improving the functional avidity of effector T cells is critical in overcoming inhibitory factors within the tumor microenvironment and eliciting tumor regression. We have found that Cish, a member of the suppressor of cytokine signaling (SOCS) family, is induced by TCR stimulation in CD8(+) T cells...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Palmer, Douglas C., Guittard, Geoffrey C., Franco, Zulmarie, Crompton, Joseph G., Eil, Robert L., Patel, Shashank J., Ji, Yun, Van Panhuys, Nicholas, Klebanoff, Christopher A., Sukumar, Madhusudhanan, Clever, David, Chichura, Anna, Roychoudhuri, Rahul, Varma, Rajat, Wang, Ena, Gattinoni, Luca, Marincola, Francesco M., Balagopalan, Lakshmi, Samelson, Lawrence E., Restifo, Nicholas P.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647263/
https://ncbi.nlm.nih.gov/pubmed/26527801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150304
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados