Cish actively silences TCR signaling in CD8(+) T cells to maintain tumor tolerance

Improving the functional avidity of effector T cells is critical in overcoming inhibitory factors within the tumor microenvironment and eliciting tumor regression. We have found that Cish, a member of the suppressor of cytokine signaling (SOCS) family, is induced by TCR stimulation in CD8(+) T cells...

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Vydáno v:J Exp Med
Hlavní autoři: Palmer, Douglas C., Guittard, Geoffrey C., Franco, Zulmarie, Crompton, Joseph G., Eil, Robert L., Patel, Shashank J., Ji, Yun, Van Panhuys, Nicholas, Klebanoff, Christopher A., Sukumar, Madhusudhanan, Clever, David, Chichura, Anna, Roychoudhuri, Rahul, Varma, Rajat, Wang, Ena, Gattinoni, Luca, Marincola, Francesco M., Balagopalan, Lakshmi, Samelson, Lawrence E., Restifo, Nicholas P.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2015
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647263/
https://ncbi.nlm.nih.gov/pubmed/26527801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150304
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