The Ability of Sos1 to Oligomerize the Adaptor Protein LAT Is Separable from its Guanine Nucleotide Exchange Activity In Vivo

The activation of the small guanosine triphosphatase Ras by the guanine nucleotide exchange factor (GEF) Sos1 (Son of Sevenless 1) is a central feature of many receptor-stimulated signaling pathways. In developing T cells (thymocytes), Sos1-dependent activation of extracellular signal–regulated kina...

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Publicado no:Sci Signal
Main Authors: Kortum, Robert L., Balagopalan, Lakshmi, Alexander, Clayton P., Garcia, Julie, Pinski, John M., Merrill, Robert K., Nguyen, Phan H., Li, Wenmei, Agarwal, Isha, Akpan, Itoro O., Sommers, Connie L., Samelson, Lawrence E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259567/
https://ncbi.nlm.nih.gov/pubmed/24222714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2004494
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