The Ability of Sos1 to Oligomerize the Adaptor Protein LAT Is Separable from its Guanine Nucleotide Exchange Activity In Vivo

The activation of the small guanosine triphosphatase Ras by the guanine nucleotide exchange factor (GEF) Sos1 (Son of Sevenless 1) is a central feature of many receptor-stimulated signaling pathways. In developing T cells (thymocytes), Sos1-dependent activation of extracellular signal–regulated kina...

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Détails bibliographiques
Publié dans:Sci Signal
Auteurs principaux: Kortum, Robert L., Balagopalan, Lakshmi, Alexander, Clayton P., Garcia, Julie, Pinski, John M., Merrill, Robert K., Nguyen, Phan H., Li, Wenmei, Agarwal, Isha, Akpan, Itoro O., Sommers, Connie L., Samelson, Lawrence E.
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259567/
https://ncbi.nlm.nih.gov/pubmed/24222714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2004494
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