miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM Pathways

Linker for Activation of T cells (LAT) is an adapter protein that is essential for T cell function. Knock-in mice with a LAT mutation impairing calcium flux develop a fatal CD4(+) lymphoproliferative disease. miR-155 is a microRNA that is correlated with hyperproliferation in a number of cancers inc...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Rouquette-Jazdanian, Alexandre K., Kortum, Robert L., Li, Wenmei, Merrill, Robert K., Nguyen, Phan H., Samelson, Lawrence E., Sommers, Connie L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4487994/
https://ncbi.nlm.nih.gov/pubmed/26121028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131823
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