A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity

Por Yasgar, Adam, Titus, Steven A., Wang, Yuhong, Danchik, Carina, Yang, Shyh-Ming, Vasiliou, Vasilis, Jadhav, Ajit, Maloney, David J., Simeonov, Anton, Martinez, Natalia J.
Publicado no PLoS One (2017)

Correction: A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity

Por Yasgar, Adam, Titus, Steven A., Wang, Yuhong, Danchik, Carina, Yang, Shyh-Ming, Vasiliou, Vasilis, Jadhav, Ajit, Maloney, David J., Simeonov, Anton, Martinez, Natalia J.
Publicado no PLoS One (2018)

Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1)

Por Yang, Shyh-Ming, Yasgar, Adam, Miller, Bettina, Lal-Nag, Madhu, Brimacombe, Kyle, Hu, Xin, Sun, Hongmao, Wang, Amy, Xu, Xin, Nguyen, Kimloan, Oppermann, Udo, Ferrer, Marc, Vasiliou, Vasilis, Simeonov, Anton, Jadhav, Ajit, Maloney, David J.
Publicado no J Med Chem (2015)

A widely-applicable high-throughput cellular thermal shift assay (CETSA) using split Nano Luciferase

Por Martinez, Natalia J., Asawa, Rosita R., Cyr, Matthew G., Zakharov, Alexey, Urban, Daniel J., Roth, Jacob S., Wallgren, Eric, Klumpp-Thomas, Carleen, Coussens, Nathan P., Rai, Ganesha, Yang, Shyh-Ming, Hall, Matthew D., Marugan, Juan J., Simeonov, Anton, Henderson, Mark J.
Publicado no Sci Rep (2018)

DDB2 represses ovarian cancer cell dedifferentiation by suppressing ALDH1A1

Por Cui, Tiantian, Srivastava, Amit Kumar, Han, Chunhua, Wu, Dayong, Wani, Nissar, Liu, Lu, Gao, Zhiqin, Qu, Meihua, Zou, Ning, Zhang, Xiaoli, Yi, Ping, Yu, Jianhua, Bell, Erica H., Yang, Shyh-Ming, Maloney, David J., Zheng, Yanfang, Wani, Altaf A., Wang, Qi-En
Publicado no Cell Death Dis (2018)

Correction: A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Mode...

Por Martinez, Natalia J., Rai, Ganesha, Yasgar, Adam, Lea, Wendy A., Sun, Hongmao, Wang, Yuhong, Luci, Diane K., Yang, Shyh-Ming, Nishihara, Kana, Takeda, Shunichi, Mohiuddin, Earnshaw, Irina, Okada, Tetsuya, Mori, Kazutoshi, Wilson, Kelli, Riggins, Gregory J., Xia, Menghang, Grimaldi, Maurizio, Jadhav, Ajit, Maloney, David J., Simeonov, Anton
Publicado no PLoS One (2016)

Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity

Por Yang, Shyh-Ming, Martinez, Natalia J., Yasgar, Adam, Danchik, Carina, Johansson, Catrine, Wang, Yuhong, Baljinnyam, Bolormaa, Wang, Amy Q., Xu, Xin, Shah, Pranav, Cheff, Dorian, Wang, Xinran S., Roth, Jacob, Lal-Nag, Madhu, Dunford, James E., Oppermann, Udo, Vasiliou, Vasilis, Simeonov, Anton, Jadhav, Ajit, Maloney, David J.
Publicado no J Med Chem (2018)

A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models

Por Martinez, Natalia J., Rai, Ganesha, Yasgar, Adam, Lea, Wendy A., Sun, Hongmao, Wang, Yuhong, Luci, Diane K., Yang, Shyh-Ming, Nishihara, Kana, Takeda, Shunichi, Sagor, Mohiuddin, Earnshaw, Irina, Okada, Tetsuya, Mori, Kazutoshi, Wilson, Kelli, Riggins, Gregory J., Xia, Menghang, Grimaldi, Maurizio, Jadhav, Ajit, Maloney, David J., Simeonov, Anton
Publicado no PLoS One (2016)

Discovery and Optimization of potent, cell-active pyrazole-based inhibitors of Lactate Dehydrogenase (LDH)

Por Rai, Ganesha, Brimacombe, Kyle R., Mott, Bryan T., Urban, Daniel J., Hu, Xin, Yang, Shyh-Ming, Lee, Tobie D., Cheff, Dorian M., Kouznetsova, Jennifer, Benavides, Gloria A., Pohida, Katie, Kuenstner, Eric J., Luci, Diane K., Lukacs, Christine M., Davies, Douglas R., Dranow, David M., Zhu, Hu, Sulikowski, Gary, Moore, William J., Stott, Gordon M., Flint, Andrew J., Hall, Matthew D., Darley-Usmar, Victor M., Neckers, Leonard M., Dang, Chi V., Waterson, Alex G., Simeonov, Anton, Jadhav, Ajit, Maloney, David J.
Publicado no J Med Chem (2017)