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A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models
The endoplasmic reticulum (ER) is involved in Ca(2+) signaling and protein folding. ER Ca(2+) depletion and accumulation of unfolded proteins activate the molecular chaperone GRP78 (glucose-regulated protein 78) which in turn triggers the ER stress response (ERSR) pathway aimed to restore ER homeost...
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Publicado no: | PLoS One |
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Main Authors: | , , , , , , , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Public Library of Science
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5003374/ https://ncbi.nlm.nih.gov/pubmed/27570969 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161486 |
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