Cell-based assays to support the profiling of small molecules with histone methyltransferase and demethylase modulatory activity

Por Martinez, Natalia J., Simeonov, Anton
Publicado no Drug Discov Today Technol (2015)

Argonaute2 expression is post-transcriptionally coupled to microRNA abundance

Por Martinez, Natalia J., Gregory, Richard I.
Publicado em 2013

The interplay between transcription factors and microRNAs in genome-scale regulatory networks

Por Martinez, Natalia J., Walhout, Albertha J. M.
Publicado em 2009

High throughput fluorescence imaging approaches for drug discovery using in vitro and in vivo three-dimensional models

Por Martinez, Natalia J., Titus, Steven A., Wagner, Amanda K., Simeonov, Anton
Publicado no Expert Opin Drug Discov (2015)

Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation

Por Chang, Hao-Ming, Martinez, Natalia J., Thornton, James E., Gregory, Richard I.
Publicado em 2012

The co-chaperones Fkbp4/5 control Argonaute2 expression and facilitate RISC assembly

Por Martinez, Natalia J., Chang, Hao-Ming, Borrajo, Jacob de Riba, Gregory, Richard I.
Publicado em 2013

Genome-scale spatiotemporal analysis of Caenorhabditis elegans microRNA promoter activity

Por Martinez, Natalia J., Ow, Maria C., Reece-Hoyes, John S., Barrasa, M. Inmaculada, Ambros, Victor R., Walhout, Albertha J.M.
Publicado em 2008

The FLYWCH transcription factors FLH-1, FLH-2, and FLH-3 repress embryonic expression of microRNA genes in C. elegans

Por Ow, Maria C., Martinez, Natalia J., Olsen, Philip H., Silverman, Howard S., Barrasa, M. Inmaculada, Conradt, Barbara, Walhout, Albertha J.M., Ambros, Victor
Publicado em 2008

A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity

Por Yasgar, Adam, Titus, Steven A., Wang, Yuhong, Danchik, Carina, Yang, Shyh-Ming, Vasiliou, Vasilis, Jadhav, Ajit, Maloney, David J., Simeonov, Anton, Martinez, Natalia J.
Publicado no PLoS One (2017)

Correction: A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity

Por Yasgar, Adam, Titus, Steven A., Wang, Yuhong, Danchik, Carina, Yang, Shyh-Ming, Vasiliou, Vasilis, Jadhav, Ajit, Maloney, David J., Simeonov, Anton, Martinez, Natalia J.
Publicado no PLoS One (2018)

A C. elegans genome-scale microRNA network contains composite feedback motifs with high flux capacity

Por Martinez, Natalia J., Ow, Maria C., Barrasa, M. Inmaculada, Hammell, Molly, Sequerra, Reynaldo, Doucette-Stamm, Lynn, Roth, Frederick P., Ambros, Victor R., Walhout, Albertha J.M.
Publicado em 2008

Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing

Por Shen, Min, Asawa, Rosita, Zhang, Ya-Qin, Cunningham, Elizabeth, Sun, Hongmao, Tropsha, Alexander, Janzen, William P., Muratov, Eugene N., Capuzzi, Stephen J., Farag, Sherif, Jadhav, Ajit, Blatt, Julie, Simeonov, Anton, Martinez, Natalia J.
Publicado no Oncotarget (2017)

A stele-enriched gene regulatory network in the Arabidopsis root

Por Brady, Siobhan M, Zhang, Lifang, Megraw, Molly, Martinez, Natalia J, Jiang, Eric, Yi, Charles S, Liu, Weilin, Zeng, Anna, Taylor-Teeples, Mallorie, Kim, Dahae, Ahnert, Sebastian, Ohler, Uwe, Ware, Doreen, Walhout, Albertha J M, Benfey, Philip N
Publicado em 2011

A widely-applicable high-throughput cellular thermal shift assay (CETSA) using split Nano Luciferase

Por Martinez, Natalia J., Asawa, Rosita R., Cyr, Matthew G., Zakharov, Alexey, Urban, Daniel J., Roth, Jacob S., Wallgren, Eric, Klumpp-Thomas, Carleen, Coussens, Nathan P., Rai, Ganesha, Yang, Shyh-Ming, Hall, Matthew D., Marugan, Juan J., Simeonov, Anton, Henderson, Mark J.
Publicado no Sci Rep (2018)

Correction: A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Mode...

Por Martinez, Natalia J., Rai, Ganesha, Yasgar, Adam, Lea, Wendy A., Sun, Hongmao, Wang, Yuhong, Luci, Diane K., Yang, Shyh-Ming, Nishihara, Kana, Takeda, Shunichi, Mohiuddin, Earnshaw, Irina, Okada, Tetsuya, Mori, Kazutoshi, Wilson, Kelli, Riggins, Gregory J., Xia, Menghang, Grimaldi, Maurizio, Jadhav, Ajit, Maloney, David J., Simeonov, Anton
Publicado no PLoS One (2016)

Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity

Por Yang, Shyh-Ming, Martinez, Natalia J., Yasgar, Adam, Danchik, Carina, Johansson, Catrine, Wang, Yuhong, Baljinnyam, Bolormaa, Wang, Amy Q., Xu, Xin, Shah, Pranav, Cheff, Dorian, Wang, Xinran S., Roth, Jacob, Lal-Nag, Madhu, Dunford, James E., Oppermann, Udo, Vasiliou, Vasilis, Simeonov, Anton, Jadhav, Ajit, Maloney, David J.
Publicado no J Med Chem (2018)

A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models

Por Martinez, Natalia J., Rai, Ganesha, Yasgar, Adam, Lea, Wendy A., Sun, Hongmao, Wang, Yuhong, Luci, Diane K., Yang, Shyh-Ming, Nishihara, Kana, Takeda, Shunichi, Sagor, Mohiuddin, Earnshaw, Irina, Okada, Tetsuya, Mori, Kazutoshi, Wilson, Kelli, Riggins, Gregory J., Xia, Menghang, Grimaldi, Maurizio, Jadhav, Ajit, Maloney, David J., Simeonov, Anton
Publicado no PLoS One (2016)

Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays

Por Urban, Daniel J., Martinez, Natalia J., Davis, Mindy I., Brimacombe, Kyle R., Cheff, Dorian M., Lee, Tobie D., Henderson, Mark J., Titus, Steven A., Pragani, Rajan, Rohde, Jason M., Liu, Li, Fang, Yuhong, Karavadhi, Surendra, Shah, Pranav, Lee, Olivia W., Wang, Amy, McIver, Andrew, Zheng, Hongchao, Wang, Xiaodong, Xu, Xin, Jadhav, Ajit, Simeonov, Anton, Shen, Min, Boxer, Matthew B., Hall, Matthew D.
Publicado no Sci Rep (2017)