A widely-applicable high-throughput cellular thermal shift assay (CETSA) using split Nano Luciferase

Assessment of the interactions between a drug and its protein target in a physiologically relevant cellular environment constitutes a major challenge in the pre-clinical drug discovery space. The Cellular Thermal Shift Assay (CETSA) enables such an assessment by quantifying the changes in the therma...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Martinez, Natalia J., Asawa, Rosita R., Cyr, Matthew G., Zakharov, Alexey, Urban, Daniel J., Roth, Jacob S., Wallgren, Eric, Klumpp-Thomas, Carleen, Coussens, Nathan P., Rai, Ganesha, Yang, Shyh-Ming, Hall, Matthew D., Marugan, Juan J., Simeonov, Anton, Henderson, Mark J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013488/
https://ncbi.nlm.nih.gov/pubmed/29930256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-27834-y
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