Discovery and Optimization of potent, cell-active pyrazole-based inhibitors of Lactate Dehydrogenase (LDH)

We report the discovery and medicinal chemistry optimization of a novel series of pyrazole-based inhibitors of human lactate dehydrogenase (LDH). Utilization of a quantitative high-throughput screening paradigm facilitated hit identification while structure-based design and multi-parameter optimizat...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Rai, Ganesha, Brimacombe, Kyle R., Mott, Bryan T., Urban, Daniel J., Hu, Xin, Yang, Shyh-Ming, Lee, Tobie D., Cheff, Dorian M., Kouznetsova, Jennifer, Benavides, Gloria A., Pohida, Katie, Kuenstner, Eric J., Luci, Diane K., Lukacs, Christine M., Davies, Douglas R., Dranow, David M., Zhu, Hu, Sulikowski, Gary, Moore, William J., Stott, Gordon M., Flint, Andrew J., Hall, Matthew D., Darley-Usmar, Victor M., Neckers, Leonard M., Dang, Chi V., Waterson, Alex G., Simeonov, Anton, Jadhav, Ajit, Maloney, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5894102/
https://ncbi.nlm.nih.gov/pubmed/29120638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00941
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados