Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties

Lactate dehydrogenase (LDH) catalyzes the conversion of pyruvate to lactate, with concomitant oxidation of reduced nicotinamide adenine dinucleotide as the final step in the glycolytic pathway. Glycolysis plays an important role in the metabolic plasticity of cancer cells and has long been recognize...

সম্পূর্ণ বিবরণ

সংরক্ষণ করুন:
গ্রন্থ-পঞ্জীর বিবরন
প্রকাশিত:J Med Chem
প্রধান লেখক: Rai, Ganesha, Urban, Daniel J., Mott, Bryan T., Hu, Xin, Yang, Shyh-Ming, Benavides, Gloria A., Johnson, Michelle S., Squadrito, Giuseppe L., Brimacombe, Kyle R., Lee, Tobie D., Cheff, Dorian M., Zhu, Hu, Henderson, Mark J., Pohida, Katherine, Sulikowski, Gary A., Dranow, David M., Kabir, Md, Shah, Pranav, Padilha, Elias, Tao, Dingyin, Fang, Yuhong, Christov, Plamen P., Kim, Kwangho, Jana, Somnath, Muttil, Pavan, Anderson, Tamara, Kunda, Nitesh K., Hathaway, Helen J., Kusewitt, Donna F., Oshima, Nobu, Cherukuri, Murali, Davies, Douglas R., Norenberg, Jeffrey P., Sklar, Larry A., Moore, William J., Dang, Chi V., Stott, Gordon M., Neckers, Leonard, Flint, Andrew J., Darley-Usmar, Victor M., Simeonov, Anton, Waterson, Alex G., Jadhav, Ajit, Hall, Matthew D., Maloney, David J.
বিন্যাস: Artigo
ভাষা:Inglês
প্রকাশিত: 2020
বিষয়গুলি:
Article
অনলাইন ব্যবহার করুন:https://ncbi.nlm.nih.gov/pmc/articles/PMC7830743/
https://ncbi.nlm.nih.gov/pubmed/32902275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00916
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