Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties

Lactate dehydrogenase (LDH) catalyzes the conversion of pyruvate to lactate, with concomitant oxidation of reduced nicotinamide adenine dinucleotide as the final step in the glycolytic pathway. Glycolysis plays an important role in the metabolic plasticity of cancer cells and has long been recognize...

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Publicado en:J Med Chem
Main Authors: Rai, Ganesha, Urban, Daniel J., Mott, Bryan T., Hu, Xin, Yang, Shyh-Ming, Benavides, Gloria A., Johnson, Michelle S., Squadrito, Giuseppe L., Brimacombe, Kyle R., Lee, Tobie D., Cheff, Dorian M., Zhu, Hu, Henderson, Mark J., Pohida, Katherine, Sulikowski, Gary A., Dranow, David M., Kabir, Md, Shah, Pranav, Padilha, Elias, Tao, Dingyin, Fang, Yuhong, Christov, Plamen P., Kim, Kwangho, Jana, Somnath, Muttil, Pavan, Anderson, Tamara, Kunda, Nitesh K., Hathaway, Helen J., Kusewitt, Donna F., Oshima, Nobu, Cherukuri, Murali, Davies, Douglas R., Norenberg, Jeffrey P., Sklar, Larry A., Moore, William J., Dang, Chi V., Stott, Gordon M., Neckers, Leonard, Flint, Andrew J., Darley-Usmar, Victor M., Simeonov, Anton, Waterson, Alex G., Jadhav, Ajit, Hall, Matthew D., Maloney, David J.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7830743/
https://ncbi.nlm.nih.gov/pubmed/32902275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00916
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