Optimization of ether and aniline based inhibitors of lactate dehydrogenase

Lactate dehydrogenase (LDH) is a critical enzyme in the glycolytic metabolism pathway that is used by many tumor cells. Inhibitors of LDH may be expected to inhibit the metabolic processes in cancer cells and thus selectively delay or inhibit growth in transformed versus normal cells. We have previo...

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Publicado no:Bioorg Med Chem Lett
Main Authors: Christov, Plamen P., Kim, Kwangho, Jana, Somnath, Romaine, Ian M., Rai, Ganesha, Mott, Bryan T., Allweil, Alexander A., Lamers, Alexander, Brimacombe, Kyle R., Urban, Daniel J., Lee, Tobie D., Hu, Xin, Lukacs, Christine M., Davies, Douglas R., Jadhav, Ajit, Hall, Matthew D., Green, Neal, Moore, William J., Stott, Gordon M., Flint, Andrew J., Maloney, David J., Sulikowski, Gary A., Waterson, Alex G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8113097/
https://ncbi.nlm.nih.gov/pubmed/33771585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2021.127974
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