Identification of Novel Plasmodium falciparum Hexokinase Inhibitors with Antiparasitic Activity

Plasmodium falciparum, the deadliest species of malaria parasites, is dependent on glycolysis for the generation of ATP during the pathogenic red blood cell stage. Hexokinase (HK) catalyzes the first step in glycolysis, transferring the γ-phosphoryl group of ATP to glucose to yield glucose-6-phospha...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Davis, Mindy I., Patrick, Stephen L., Blanding, Walker M., Dwivedi, Varun, Suryadi, Jimmy, Golden, Jennifer E., Coussens, Nathan P., Lee, Olivia W., Shen, Min, Boxer, Matthew B., Hall, Matthew D., Sharlow, Elizabeth R., Drew, Mark E., Morris, James C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5038330/
https://ncbi.nlm.nih.gov/pubmed/27458230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00914-16
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