Biochemical and Antiparasitic Properties of Inhibitors of the Plasmodium falciparum Calcium-Dependent Protein Kinase PfCDPK1

PfCDPK1 is a Plasmodium falciparum calcium-dependent protein kinase, which has been identified as a potential target for novel antimalarial chemotherapeutics. In order to further investigate the role of PfCDPK1, we established a high-throughput in vitro biochemical assay and used it to screen a libr...

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Bibliografiske detaljer
Main Authors: Ansell, Keith H., Jones, Hayley M., Whalley, David, Hearn, Alisdair, Taylor, Debra L., Patin, Emmanuel C., Chapman, Timothy M., Osborne, Simon A., Wallace, Claire, Birchall, Kristian, Large, Jonathan, Bouloc, Nathalie, Smiljanic-Hurley, Ela, Clough, Barbara, Moon, Robert W., Green, Judith L., Holder, Anthony A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187893/
https://ncbi.nlm.nih.gov/pubmed/25070106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02959-14
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