New Anti-tuberculosis Agents Amongst Known Drugs

Autor Lougheed, Kathryn E.A., Taylor, Debra L., Osborne, Simon A., Bryans, Justin S., Buxton, Roger S.
Vydáno 2009

Targeting the Malaria Parasite cGMP-Dependent Protein Kinase to Develop New Drugs

Autor Baker, David A., Matralis, Alexios N., Osborne, Simon A., Large, Jonathan M., Penzo, Maria
Vydáno v Front Microbiol (2020)

Pharmacological Inhibition of ULK1 Kinase Blocks Mammalian Target of Rapamycin (mTOR)-dependent Autophagy

Autor Petherick, Katy J., Conway, Owen J. L., Mpamhanga, Chido, Osborne, Simon A., Kamal, Ahmad, Saxty, Barbara, Ganley, Ian G.
Vydáno v J Biol Chem (2015)

Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy.

Autor Petherick, Katy J., Conway, Owen J. L., Mpamhanga, Chido, Osborne, Simon A., Kamal, Ahmad, Saxty, Barbara, Ganley, Ian G.
Vydáno v J Biol Chem (2015)

Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis

Autor Chapman, Timothy M., Bouloc, Nathalie, Buxton, Roger S., Chugh, Jasveen, Lougheed, Kathryn E.A., Osborne, Simon A., Saxty, Barbara, Smerdon, Stephen J., Taylor, Debra L., Whalley, David
Vydáno 2012

Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues()

Autor Large, Jonathan M., Osborne, Simon A., Smiljanic-Hurley, Ela, Ansell, Keith H., Jones, Hayley M., Taylor, Debra L., Clough, Barbara, Green, Judith L., Holder, Anthony A.
Vydáno 2013

Corrigendum to “Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogu...

Autor Large, Jonathan M., Osborne, Simon A., Smiljanic-Hurley, Ela, Ansell, Keith H., Jones, Hayley M., Taylor, Debra L., Clough, Barbara, Green, Judith L., Holder, Anthony A.
Vydáno 2014

Optimization of an Imidazopyridazine Series of Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 (PfCDPK1)

Autor Chapman, Timothy M., Osborne, Simon A., Wallace, Claire, Birchall, Kristian, Bouloc, Nathalie, Jones, Hayley M., Ansell, Keith H., Taylor, Debra L., Clough, Barbara, Green, Judith L., Holder, Anthony A.
Vydáno 2014

Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1)

Autor Chapman, Timothy M., Osborne, Simon A., Bouloc, Nathalie, Large, Jonathan M., Wallace, Claire, Birchall, Kristian, Ansell, Keith H., Jones, Hayley M., Taylor, Debra, Clough, Barbara, Green, Judith L., Holder, Anthony A.
Vydáno 2013

Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG)

Autor Tsagris, Denise J., Birchall, Kristian, Bouloc, Nathalie, Large, Jonathan M., Merritt, Andy, Smiljanic-Hurley, Ela, Wheldon, Mary, Ansell, Keith H., Kettleborough, Catherine, Whalley, David, Stewart, Lindsay B., Bowyer, Paul W., Baker, David A., Osborne, Simon A.
Vydáno v Bioorg Med Chem Lett (2018)

Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents

Autor Lougheed, Kathryn E.A., Osborne, Simon A., Saxty, Barbara, Whalley, David, Chapman, Tim, Bouloc, Nathalie, Chugh, Jasveen, Nott, Timothy J., Patel, Dony, Spivey, Vicky L., Kettleborough, Catherine A., Bryans, Justin S., Taylor, Debra L., Smerdon, Stephen J., Buxton, Roger S.
Vydáno 2011

Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines

Autor Large, Jonathan M., Birchall, Kristian, Bouloc, Nathalie S., Merritt, Andy T., Smiljanic-Hurley, Ela, Tsagris, Denise J., Wheldon, Mary C., Ansell, Keith H., Coombs, Peter J., Kettleborough, Catherine A., Whalley, David, Stewart, Lindsay B., Bowyer, Paul W., Baker, David A., Osborne, Simon A.
Vydáno v Bioorg Med Chem Lett (2019)

Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty

Autor Large, Jonathan M., Birchall, Kristian, Bouloc, Nathalie S., Merritt, Andy T., Smiljanic-Hurley, Ela, Tsagris, Denise J., Wheldon, Mary C., Ansell, Keith H., Coombs, Peter J., Kettleborough, Catherine A., Whalley, David, Stewart, Lindsay B., Bowyer, Paul W., Baker, David A., Osborne, Simon A.
Vydáno v Bioorg Med Chem Lett (2019)

Development of Chemical Entities Endowed with Potent Fast-Killing Properties against Plasmodium falciparum Malaria Parasites

Autor Matralis, Alexios N., Malik, Adnan, Penzo, Maria, Moreno, Inmaculada, Almela, Maria J., Camino, Isabel, Crespo, Benigno, Saadeddin, Anas, Ghidelli-Disse, Sonja, Rueda, Lourdes, Calderon, Felix, Osborne, Simon A., Drewes, Gerard, Böesche, Markus, Fernández-Álvaro, Elena, Martin Hernando, Jose Ignacio, Baker, David A.
Vydáno v J Med Chem (2019)

Biochemical and Antiparasitic Properties of Inhibitors of the Plasmodium falciparum Calcium-Dependent Protein Kinase PfCDPK1

Autor Ansell, Keith H., Jones, Hayley M., Whalley, David, Hearn, Alisdair, Taylor, Debra L., Patin, Emmanuel C., Chapman, Timothy M., Osborne, Simon A., Wallace, Claire, Birchall, Kristian, Large, Jonathan, Bouloc, Nathalie, Smiljanic-Hurley, Ela, Clough, Barbara, Moon, Robert W., Green, Judith L., Holder, Anthony A.
Vydáno 2014

Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Paras...

Autor Green, Judith L., Moon, Robert W., Whalley, David, Bowyer, Paul W., Wallace, Claire, Rochani, Ankit, Nageshan, Rishi K., Howell, Steven A., Grainger, Munira, Jones, Hayley M., Ansell, Keith H., Chapman, Timothy M., Taylor, Debra L., Osborne, Simon A., Baker, David A., Tatu, Utpal, Holder, Anthony A.
Vydáno v Antimicrob Agents Chemother (2016)

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission

Autor Baker, David A., Stewart, Lindsay B., Large, Jonathan M., Bowyer, Paul W., Ansell, Keith H., Jiménez-Díaz, María B., El Bakkouri, Majida, Birchall, Kristian, Dechering, Koen J., Bouloc, Nathalie S., Coombs, Peter J., Whalley, David, Harding, Denise J., Smiljanic-Hurley, Ela, Wheldon, Mary C., Walker, Eloise M., Dessens, Johannes T., Lafuente, María José, Sanz, Laura M., Gamo, Francisco-Javier, Ferrer, Santiago B., Hui, Raymond, Bousema, Teun, Angulo-Barturén, Iñigo, Merritt, Andy T., Croft, Simon L., Gutteridge, Winston E., Kettleborough, Catherine A., Osborne, Simon A.
Vydáno v Nat Commun (2017)