Pharmacological Inhibition of ULK1 Kinase Blocks Mammalian Target of Rapamycin (mTOR)-dependent Autophagy

Autophagy is a cell-protective and degradative process that recycles damaged and long-lived cellular components. Cancer cells are thought to take advantage of autophagy to help them to cope with the stress of tumorigenesis; thus targeting autophagy is an attractive therapeutic approach. However, the...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Petherick, Katy J., Conway, Owen J. L., Mpamhanga, Chido, Osborne, Simon A., Kamal, Ahmad, Saxty, Barbara, Ganley, Ian G.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2015
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Reports
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416842/
https://ncbi.nlm.nih.gov/pubmed/25833948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C114.627778
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