Pharmacological Inhibition of ULK1 Kinase Blocks Mammalian Target of Rapamycin (mTOR)-dependent Autophagy

Autophagy is a cell-protective and degradative process that recycles damaged and long-lived cellular components. Cancer cells are thought to take advantage of autophagy to help them to cope with the stress of tumorigenesis; thus targeting autophagy is an attractive therapeutic approach. However, the...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:J Biol Chem
Hlavní autoři: Petherick, Katy J., Conway, Owen J. L., Mpamhanga, Chido, Osborne, Simon A., Kamal, Ahmad, Saxty, Barbara, Ganley, Ian G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416842/
https://ncbi.nlm.nih.gov/pubmed/25833948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C114.627778
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky