The mTOR (Mammalian Target of Rapamycin) Kinase Maintains Integrity of mTOR Complex 2

In higher eukaryotes, growth factors promote anabolic processes and stimulate cell growth, proliferation, and survival by activation of the phosphoinositide 3-kinase (PI3K)/Akt pathway. Deregulation of PI3K/Akt signaling is linked to human diseases, including cancer and metabolic disorders. The PI3K...

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Hlavní autoři: Chen, Chien-Hung, Sarbassov, Dos D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220582/
https://ncbi.nlm.nih.gov/pubmed/21965657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.282590
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