The mTOR (Mammalian Target of Rapamycin) Kinase Maintains Integrity of mTOR Complex 2

In higher eukaryotes, growth factors promote anabolic processes and stimulate cell growth, proliferation, and survival by activation of the phosphoinositide 3-kinase (PI3K)/Akt pathway. Deregulation of PI3K/Akt signaling is linked to human diseases, including cancer and metabolic disorders. The PI3K...

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Bibliographic Details
Main Authors: Chen, Chien-Hung, Sarbassov, Dos D.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220582/
https://ncbi.nlm.nih.gov/pubmed/21965657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.282590
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