The Mechanism of Insulin-stimulated 4E-BP Protein Binding to Mammalian Target of Rapamycin (mTOR) Complex 1 and Its Contribution to mTOR Complex 1 Signaling

Insulin activation of mTOR complex 1 is accompanied by enhanced binding of substrates. We examined the mechanism and contribution of this enhancement to insulin activation of mTORC1 signaling in 293E and HeLa cells. In 293E, insulin increased the amount of mTORC1 retrieved by the transiently express...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Rapley, Joseph, Oshiro, Noriko, Ortiz-Vega, Sara, Avruch, Joseph
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2011
Gaiak:
Signal Transduction
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207408/
https://ncbi.nlm.nih.gov/pubmed/21914810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.245449
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