Cardiac Restricted Overexpression of Kinase-dead Mammalian Target of Rapamycin (mTOR) Mutant Impairs the mTOR-mediated Signaling and Cardiac Function

Mammalian target of rapamycin (mTOR) is a key regulator for cell growth through modulating components of the translation machinery. Previously, numerous pharmacological studies using rapamycin suggested that mTOR has an important role in regulating cardiac hypertrophic growth. To further investigate...

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Detalhes bibliográficos
Main Authors: Shen, Wei-Hua, Chen, Zhuang, Shi, Shu, Chen, Hanying, Zhu, Wuqiang, Penner, Anne, Bu, Guixue, Li, Wei, Boyle, David W., Rubart, Michael, Field, Loren J., Abraham, Robert, Liechty, Edward A., Shou, Weinian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376248/
https://ncbi.nlm.nih.gov/pubmed/18326485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801510200
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