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Rapamycin and mTOR kinase inhibitors

Mammalian target of rapamycin (mTOR) is a protein kinase that controls cell growth, proliferation, and survival. mTOR signaling is often upregulated in cancer and there is great interest in developing drugs that target this enzyme. Rapamycin and its analogs bind to a domain separate from the catalyt...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Ballou, Lisa M., Lin, Richard Z.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer-Verlag 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698317/
https://ncbi.nlm.nih.gov/pubmed/19568796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12154-008-0003-5
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