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Rapamycin and mTOR kinase inhibitors

Mammalian target of rapamycin (mTOR) is a protein kinase that controls cell growth, proliferation, and survival. mTOR signaling is often upregulated in cancer and there is great interest in developing drugs that target this enzyme. Rapamycin and its analogs bind to a domain separate from the catalyt...

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Bibliografische gegevens
Hoofdauteurs: Ballou, Lisa M., Lin, Richard Z.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer-Verlag 2008
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698317/
https://ncbi.nlm.nih.gov/pubmed/19568796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12154-008-0003-5
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