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Rapamycin and mTOR kinase inhibitors

Mammalian target of rapamycin (mTOR) is a protein kinase that controls cell growth, proliferation, and survival. mTOR signaling is often upregulated in cancer and there is great interest in developing drugs that target this enzyme. Rapamycin and its analogs bind to a domain separate from the catalyt...

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Bibliografiska uppgifter
Huvudupphovsmän: Ballou, Lisa M., Lin, Richard Z.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer-Verlag 2008
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698317/
https://ncbi.nlm.nih.gov/pubmed/19568796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12154-008-0003-5
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