The mTOR kinase inhibitor rapamycin decreases iNOS mRNA stability in astrocytes

BACKGROUND: Reactive astrocytes are capable of producing a variety of pro-inflammatory mediators and potentially neurotoxic compounds, including nitric oxide (NO). High amounts of NO are synthesized following up-regulation of inducible NO synthase (iNOS). The expression of iNOS is tightly regulated...

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Bibliographic Details
Main Authors: Lisi, Lucia, Navarra, Pierluigi, Feinstein, Douglas L, Dello Russo, Cinzia
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025854/
https://ncbi.nlm.nih.gov/pubmed/21208419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-8-1
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