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The mTOR kinase inhibitor rapamycin decreases iNOS mRNA stability in astrocytes
BACKGROUND: Reactive astrocytes are capable of producing a variety of pro-inflammatory mediators and potentially neurotoxic compounds, including nitric oxide (NO). High amounts of NO are synthesized following up-regulation of inducible NO synthase (iNOS). The expression of iNOS is tightly regulated...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
BioMed Central
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3025854/ https://ncbi.nlm.nih.gov/pubmed/21208419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-8-1 |
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