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Acute doxorubicin cardiotoxicity is associated with p53-induced inhibition of the mTOR pathway

BACKGROUND: Doxorubicin (DOX) is used to treat childhood and adult cancer. DOX treatment is associated with both acute and chronic cardiotoxicity. The cardiotoxic effects of DOX are cumulative, limiting its chemotherapeutic dose. Free radical generation and p53-dependent apoptosis are thought to con...

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書誌詳細
主要な著者: Zhu, Wuqiang, Soonpaa, Mark H., Chen, Hanying, Shen, Weihua, Payne, R. Mark, Liechty, Edward A., Caldwell, Randall L., Shou, Weinian, Field, Loren J.
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630181/
https://ncbi.nlm.nih.gov/pubmed/19103993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.108.799700
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