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Acute doxorubicin cardiotoxicity is associated with p53-induced inhibition of the mTOR pathway
BACKGROUND: Doxorubicin (DOX) is used to treat childhood and adult cancer. DOX treatment is associated with both acute and chronic cardiotoxicity. The cardiotoxic effects of DOX are cumulative, limiting its chemotherapeutic dose. Free radical generation and p53-dependent apoptosis are thought to con...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2008
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2630181/ https://ncbi.nlm.nih.gov/pubmed/19103993 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.108.799700 |
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