Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents

PknB is an essential serine/threonine kinase of Mycobacterium tuberculosis with possible roles in a number of signalling pathways involved in cell division and metabolism. We screened a library of >50,000 compounds for inhibitors of the in vitro phosphorylation of GarA (Rv1827) by PknB and identi...

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Detalhes bibliográficos
Main Authors: Lougheed, Kathryn E.A., Osborne, Simon A., Saxty, Barbara, Whalley, David, Chapman, Tim, Bouloc, Nathalie, Chugh, Jasveen, Nott, Timothy J., Patel, Dony, Spivey, Vicky L., Kettleborough, Catherine A., Bryans, Justin S., Taylor, Debra L., Smerdon, Stephen J., Buxton, Roger S.
Formato: Artigo
Idioma:Inglês
Publicado em: Churchill Livingstone 2011
Assuntos:
Drug Discovery and Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158675/
https://ncbi.nlm.nih.gov/pubmed/21482481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tube.2011.03.005
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