Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1)

A series of imidazopyridazines which are potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) was identified from a high-throughput screen against the isolated enzyme. Subsequent exploration of the SAR and optimisation has yielded leading members which show promisi...

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Bibliografiske detaljer
Main Authors: Chapman, Timothy M., Osborne, Simon A., Bouloc, Nathalie, Large, Jonathan M., Wallace, Claire, Birchall, Kristian, Ansell, Keith H., Jones, Hayley M., Taylor, Debra, Clough, Barbara, Green, Judith L., Holder, Anthony A.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Science Ltd 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898741/
https://ncbi.nlm.nih.gov/pubmed/23570789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.03.017
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