Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1)

A series of imidazopyridazines which are potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) was identified from a high-throughput screen against the isolated enzyme. Subsequent exploration of the SAR and optimisation has yielded leading members which show promisi...

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Autors principals: Chapman, Timothy M., Osborne, Simon A., Bouloc, Nathalie, Large, Jonathan M., Wallace, Claire, Birchall, Kristian, Ansell, Keith H., Jones, Hayley M., Taylor, Debra, Clough, Barbara, Green, Judith L., Holder, Anthony A.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier Science Ltd 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898741/
https://ncbi.nlm.nih.gov/pubmed/23570789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.03.017
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