Isolation of an endotoxin–MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations

Host proinflammatory responses to minute amounts of endotoxins derived from many Gram-negative bacteria require the interaction of lipopolysaccharide-binding protein (LBP), CD14, Toll-like receptor 4 (TLR4) and MD-2. Optimal sensitivity to endotoxin requires an ordered series of endotoxin–protein an...

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Detalhes bibliográficos
Main Authors: Gioannini, Theresa L., Teghanemt, Athmane, Zhang, DeSheng, Coussens, Nathan P., Dockstader, Wendie, Ramaswamy, S., Weiss, Jerrold P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC384716/
https://ncbi.nlm.nih.gov/pubmed/15010525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0306906101
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