Endotoxin·albumin complexes transfer endotoxin monomers to MD-2 resulting in activation of Toll-Like Receptor-4()

Response to Gram-negative bacteria (GNB) is partially mediated by the recognition of GNB-derived endotoxin (E) by host cells. Potent host response to E depends on the sequential interaction of E with lipopolysaccharide binding protein (LBP), CD14, MD-2 and Toll-Like Receptor 4 (TLR4). While CD14 fac...

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Main Authors: Esparza, Gregory A., Teghanemt, Athmane, Zhang, DeSheng, Gioannini, Theresa L., Weiss, Jerrold P.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636710/
https://ncbi.nlm.nih.gov/pubmed/21994253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1753425911422723
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