Isolation of Monomeric and Dimeric Secreted MD-2: ENDOTOXIN·sCD14 AND TOLL-LIKE RECEPTOR 4 ECTODOMAIN SELECTIVELY REACT WITH THE MONOMERIC FORM OF SECRETED MD-2

Potent cell activation by endotoxin requires sequential protein-endotoxin and protein-protein interactions involving lipopolysaccharide-binding protein, CD14, MD-2, and Toll-like receptor 4 (TLR4). MD-2 plays an essential role by bridging endotoxin (E) recognition initiated by lipopolysaccharide-bin...

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Auteurs principaux: Teghanemt, Athmane, Widstrom, Richard L., Gioannini, Theresa L., Weiss, Jerrold P.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2008
Sujets:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494913/
https://ncbi.nlm.nih.gov/pubmed/18519568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800672200
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