Characterization of Drug Resistance-Associated Mutations in the Human Cytomegalovirus DNA Polymerase Gene by Using Recombinant Mutant Viruses Generated from Overlapping DNA Fragme...

Por Cihlar, Tomas, Fuller, Michael D., Cherrington, Julie M.
Publicado em 1998

Assessment of Mitochondrial Toxicity in Human Cells Treated with Tenofovir: Comparison with Other Nucleoside Reverse Transcriptase Inhibitors

Por Birkus, Gabriel, Hitchcock, Michael J. M., Cihlar, Tomas
Publicado em 2002

Multiple Classes of Antiviral Agents Exhibit In Vitro Activity against Human Rhinovirus Type C

Por Mello, Chris, Aguayo, Esmeralda, Rodriguez, Madeleine, Lee, Gary, Jordan, Robert, Cihlar, Tomas, Birkus, Gabriel
Publicado em 2014

GS-8374, a Novel HIV Protease Inhibitor, Does Not Alter Glucose Homeostasis in Cultured Adipocytes or in a Healthy-Rodent Model System

Por Hruz, Paul W., Yan, Qingyun, Tsai, Luong, Koster, Joseph, Xu, Lianhong, Cihlar, Tomas, Callebaut, Christian
Publicado em 2011

Toll-Like Receptor 7 Agonist GS-9620 Induces HIV Expression and HIV-Specific Immunity in Cells from HIV-Infected Individuals on Suppressive Antiretroviral Therapy

Por Tsai, Angela, Irrinki, Alivelu, Kaur, Jasmine, Cihlar, Tomas, Kukolj, George, Sloan, Derek D., Murry, Jeffrey P.
Publicado no J Virol (2017)

Selective Intracellular Activation of a Novel Prodrug of the Human Immunodeficiency Virus Reverse Transcriptase Inhibitor Tenofovir Leads to Preferential Distribution and Accumulat...

Por Lee, William A., He, Gong-Xin, Eisenberg, Eugene, Cihlar, Tomas, Swaminathan, Swami, Mulato, Andrew, Cundy, Kenneth C.
Publicado em 2005

Novel Nucleotide Human Immunodeficiency Virus Reverse Transcriptase Inhibitor GS-9148 with a Low Nephrotoxic Potential: Characterization of Renal Transport and Accumulation

Por Cihlar, Tomas, LaFlamme, Genevieve, Fisher, Robyn, Carey, Anne C., Vela, Jennifer E., Mackman, Richard, Ray, Adrian S.
Publicado em 2009

Role of Cathepsin A and Lysosomes in the Intracellular Activation of Novel Antipapillomavirus Agent GS-9191

Por Birkus, Gabriel, Kutty, Nilima, Frey, Christian R., Shribata, Riri, Chou, Tsuifen, Wagner, Carston, McDermott, Martin, Cihlar, Tomas
Publicado em 2011

Search for small molecule activators of latent HIV

Por Geleziunas, Romas, Stepan, George, Wei, George, Yu, Helen, Graupe, Michael, Pagratis, Nikos, Barnes, Tiffany, Cihlar, Tomas, Hesselgesser, Joe
Publicado em 2012

Mutations in Multiple Domains of Gag Drive the Emergence of In Vitro Resistance to the Phosphonate-Containing HIV-1 Protease Inhibitor GS-8374

Por Stray, Kirsten M., Callebaut, Christian, Glass, Bärbel, Tsai, Luong, Xu, Lianhong, Müller, Barbara, Kräusslich, Hans-Georg, Cihlar, Tomas
Publicado em 2013

Evaluation of the Effect of Cobicistat on the In Vitro Renal Transport and Cytotoxicity Potential of Tenofovir

Por Stray, Kirsten M., Bam, Rujuta A., Birkus, Gabriel, Hao, Jia, Lepist, Eve-Irene, Yant, Stephen R., Ray, Adrian S., Cihlar, Tomas
Publicado em 2013

Quantitative microscopy of functional HIV post-entry complexes reveals association of replication with the viral capsid

Por Peng, Ke, Muranyi, Walter, Glass, Bärbel, Laketa, Vibor, Yant, Stephen R, Tsai, Luong, Cihlar, Tomas, Müller, Barbara, Kräusslich, Hans-Georg
Publicado no eLife (2014)

Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors

Por Birkus, Gabriel, Bam, Rujuta A., Willkom, Madeleine, Frey, Christian R., Tsai, Luong, Stray, Kirsten M., Yant, Stephen R., Cihlar, Tomas
Publicado no Antimicrob Agents Chemother (2015)

Human Respiratory Syncytial Virus Memphis 37 Grown in HEp-2 Cells Causes more Severe Disease in Lambs than Virus Grown in Vero Cells

Por Derscheid, Rachel J., van Geelen, Albert, McGill, Jodi L., Gallup, Jack M., Cihlar, Tomas, Sacco, Randy E., Ackermann, Mark R.
Publicado em 2013

TLR7 Agonist GS-9620 Is a Potent Inhibitor of Acute HIV-1 Infection in Human Peripheral Blood Mononuclear Cells

Por Bam, Rujuta A., Hansen, Derek, Irrinki, Alivelu, Mulato, Andrew, Jones, Gregg S., Hesselgesser, Joseph, Frey, Christian R., Cihlar, Tomas, Yant, Stephen R.
Publicado no Antimicrob Agents Chemother (2016)

Cathepsin A Is the Major Hydrolase Catalyzing the Intracellular Hydrolysis of the Antiretroviral Nucleotide Phosphonoamidate Prodrugs GS-7340 and GS-9131

Por Birkus, Gabriel, Wang, Ruth, Liu, Xiaohong, Kutty, Nilima, MacArthur, Holly, Cihlar, Tomas, Gibbs, Craig, Swaminathan, Swami, Lee, William, McDermott, Martin
Publicado em 2007

Human Respiratory Syncytial Virus Memphis 37 Causes Acute Respiratory Disease in Perinatal Lamb Lung

Por Derscheid, Rachel J., van Geelen, Albert, Gallup, Jack M., Kienzle, Thomas, Shelly, Daniel A., Cihlar, Tomas, King, Robert R., Ackermann, Mark R.
Publicado em 2014

Inhibition of Respiratory Syncytial Virus Fusion by the Small Molecule VP-14637 via Specific Interactions with F Protein

Por Douglas, Janet L., Panis, Marites L., Ho, Edmund, Lin, Kuei-Ying, Krawczyk, Steve H., Grant, Deborah M., Cai, Ruby, Swaminathan, Swami, Cihlar, Tomas
Publicado em 2003

Mechanism of Active Renal Tubular Efflux of Tenofovir

Por Ray, Adrian S., Cihlar, Tomas, Robinson, Kelly L., Tong, Leah, Vela, Jennifer E., Fuller, Michael D., Wieman, Lani M., Eisenberg, Eugene J., Rhodes, Gerry R.
Publicado em 2006

GS-8374, a Prototype Phosphonate-Containing Inhibitor of HIV-1 Protease, Effectively Inhibits Protease Mutants with Amino Acid Insertions

Por Grantz Šašková, Klára, Kožíšek, Milan, Stray, Kirsten, de Jong, Dorien, Řezáčová, Pavlína, Brynda, Jiří, van Maarseveen, Noortje M., Nijhuis, Monique, Cihlář, Tomáš, Konvalinka, Jan
Publicado em 2014