ME-07 INFLUENCE OF REGIONAL MICROENVIROMENT AND ASTROCYTE HETEROGENEITY ON ASTROCYTOMA DEVELOPMENT

Por Irvin, David, Schmid, Ralf, Bash, Ryan, Miller, C. Ryan
Publicado em 2014

Intrinsic Astrocyte Heterogeneity Influences Tumor Growth in Glioma Mouse Models

Por Irvin, David M., McNeill, Robert S., Bash, Ryan E., Miller, C. Ryan
Publicado no Brain Pathol (2016)

Reactive astrocytes potentiate tumor aggressiveness in a murine glioma resection and recurrence model

Por Okolie, Onyinyechukwu, Bago, Juli R., Schmid, Ralf S., Irvin, David M., Bash, Ryan E., Miller, C. Ryan, Hingtgen, Shawn D.
Publicado no Neuro Oncol (2016)

CSIG-14 DE-DIFFERENTIATION OF ASTROCYTES INTO GLIOBLASTOMA STEM CELLS THROUGH CORE PATHWAY MUTATIONS

Por Schmid, Ralf, Vitucci, Mark, McNeill, Robert, Bash, Ryan, Werneke, Andrea, Huey, Lauren, White, Kristen, Ewend, Matthew, Wu, Jing, Miller, C. Ryan
Publicado no Neuro Oncol (2015)

Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice

Por McNeill, Robert S., Schmid, Ralf S., Bash, Ryan E., Vitucci, Mark, White, Kristen K., Werneke, Andrea M., Constance, Brian H., Huff, Byron, Miller, C. Ryan
Publicado no J Vis Exp (2014)

ATPS-55 INFLUENCE OF MAPK AND PI3K PATHWAY MUTATIONS ON RESPONSE TO TARGETED INHIBITORS

Por McNeill, Robert S., Canoutas, Demitra A., Schmid, Ralf S., Bash, Ryan E., Constance, Brian H., Azam, Salma H., Reuther, Rachel A., Johnson, Gary L., Miller, C. Ryan
Publicado no Neuro Oncol (2015)

NT-38 MerTK AS A TARGET IN GLIOBLASTOMA

Por Wu, Jing, Huey, Lauren, Bash, Ryan E., Cohen, Stephanie M., Ewend, Matthew G., Wang, Xiaodong, Graham, Douglas K., Frye, Stephen V., Earp, H. Shelton, Miller, C. Ryan
Publicado em 2014

Cooperativity between MAPK and PI3K signaling activation is required for glioblastoma pathogenesis

Por Vitucci, Mark, Karpinich, Natalie O., Bash, Ryan E., Werneke, Andrea M., Schmid, Ralf S., White, Kristen K., McNeill, Robert S., Huff, Byron, Wang, Sophie, Van Dyke, Terry, Miller, C. Ryan
Publicado em 2013

Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide

Por Schmid, Ralf S., Simon, Jeremy M., Vitucci, Mark, McNeill, Robert S., Bash, Ryan E., Werneke, Andrea M., Huey, Lauren, White, Kristen K., Ewend, Matthew G., Wu, Jing, Miller, C. Ryan
Publicado no Neuro Oncol (2016)

Genomic profiles of low-grade murine gliomas evolve during progression to glioblastoma

Por Vitucci, Mark, Irvin, David M, McNeill, Robert S, Schmid, Ralf S, Simon, Jeremy M, Dhruv, Harshil D, Siegel, Marni B, Werneke, Andrea M, Bash, Ryan E, Kim, Seungchan, Berens, Michael E, Miller, C Ryan
Publicado no Neuro Oncol (2017)

PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition

Por McNeill, Robert S., Stroobant, Emily E., Smithberger, Erin, Canoutas, Demitra A., Butler, Madison K., Shelton, Abigail K., Patel, Shrey D., Limas, Juanita C., Skinner, Kasey R., Bash, Ryan E., Schmid, Ralf S., Miller, C. Ryan
Publicado no PLoS One (2018)

Pharmacokinetics and Efficacy of PEGylated Liposomal Doxorubicin in an Intracranial Model of Breast Cancer

Por Anders, Carey K., Adamo, Barbara, Karginova, Olga, Deal, Allison M., Rawal, Sumit, Darr, David, Schorzman, Allison, Santos, Charlene, Bash, Ryan, Kafri, Tal, Carey, Lisa, Miller, C. Ryan, Perou, Charles M., Sharpless, Norman, Zamboni, William C.
Publicado em 2013

Evolutionary etiology of high-grade astrocytomas

Por Song, Yurong, Zhang, Qian, Kutlu, Burak, Difilippantonio, Simone, Bash, Ryan, Gilbert, Debra, Yin, Chaoying, O’Sullivan, T. Norene, Yang, Chunyu, Kozlov, Serguei, Bullitt, Elizabeth, McCarthy, Ken D., Kafri, Tal, Louis, David N., Miller, C. Ryan, Hood, Leroy, Van Dyke, Terry
Publicado em 2013

MerTK as a therapeutic target in glioblastoma

Por Wu, Jing, Frady, Lauren N, Bash, Ryan E, Cohen, Stephanie M, Schorzman, Allison N, Su, Yu-Ting, Irvin, David M, Zamboni, William C, Wang, Xiaodong, Frye, Stephen V, Ewend, Matthew G, Sulman, Erik P, Gilbert, Mark R, Earp, H Shelton, Miller, C Ryan
Publicado no Neuro Oncol (2018)

Combined kinase inhibitors of MEK1/2 and either PI3K or PDGFR are efficacious in intracranial triple-negative breast cancer

Por Van Swearingen, Amanda E D, Sambade, Maria J, Siegel, Marni B, Sud, Shivani, McNeill, Robert S, Bevill, Samantha M, Chen, Xin, Bash, Ryan E, Mounsey, Louisa, Golitz, Brian T, Santos, Charlene, Deal, Allison, Parker, Joel S, Rashid, Naim, Miller, C Ryan, Johnson, Gary L, Anders, Carey K
Publicado no Neuro Oncol (2017)

Efficacy of carboplatin alone and in combination with ABT888 in intracranial murine models of BRCA-mutated and BRCA-wild-type triple negative breast cancer

Por Karginova, Olga, Siegel, Marni B., Van Swearingen, Amanda E. D., Deal, Allison M., Adamo, Barbara, Sambade, Maria J., Bazyar, Soha, Nikolaishvili-Feinberg, Nana, Bash, Ryan, O’Neal, Sara, Sandison, Katie, Parker, Joel S., Santos, Charlene, Darr, David, Zamboni, William, Lee, Yueh Z., Miller, C. Ryan, Anders, Carey K.
Publicado no Mol Cancer Ther (2015)

Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma

Por McNeill, Robert S, Canoutas, Demitra A, Stuhlmiller, Timothy J, Dhruv, Harshil D, Irvin, David M, Bash, Ryan E, Angus, Steven P, Herring, Laura E, Simon, Jeremy M, Skinner, Kasey R, Limas, Juanita C, Chen, Xin, Schmid, Ralf S, Siegel, Marni B, Van Swearingen, Amanda E D, Hadler, Michael J, Sulman, Erik P, Sarkaria, Jann N, Anders, Carey K, Graves, Lee M, Berens, Michael E, Johnson, Gary L, Miller, C Ryan
Publicado no Neuro Oncol (2017)